ABSTRACT
@#The immunodeficiency is too common in whole the world including this country. The myocardial Infarct, stroke, atherosclerosis and many other disorders develops in fact secondary immune deficit of human being. </br> We aimed to study the immune stimulating capacity of transfer factor advanced which used more than 50 countries in the world as a strong immune modulator, comparatively with other commonly used convalescents in our traditional medicine like bargashun and altan gagnuur and their membrane pereoxidase potential as well. </br> For this study were used white mouse’s with 20-25g of weights. All mouse’s were taken orally 0.05g of transfer factor advanced during 3 days 2 times per day and at the end were injected with 0.2 ml - 10% fresh red cell of sheep once which chosen as T-cell dependent stimulator test antigen. 5 days later were examined spleen index and counted newly generated antibody titer against sheep red cell. </br> The study result show that under the influence of transfer factor advanced after immunization (by 100 mg/mouse sheep red cell), the amount of cytotoxic T lymphocyte (T killer) cells among whole T lymphocyte population in the spleen and nearby lymph nodes of white mouse’s were perceptibly increased (1.43-2.33 P<0.001). It gives to conclude transfer factor advanced should have high treatment effects for several cancers, chronic liver disorders with B and C viruses hepatitis, cirrhoses etc., which develops due to deficit of T killer cell.
ABSTRACT
BackgroundThere are 137 soums of 17 provinces have plague foci in Mongolia. The 51.7% of them is case, 23.4%- low, 9.5% - high, 0.7% - hyper active. Main host of plague foci is marmot in Mongolia. According last20 year’s surveillance study, about 75.5% of Y.pestis was isolated from marmot, marmot carcassesand their flea. Human plague cases has been caused illegal hunting marmot in Mongolia. Even legaldocument which prohibited marmot hunting was appeared since 2005, people has been hunting marmotfor selling marmot meat, skin and other products. It is depends economy crises and other public issues inMongolia. Also influenced increase risk of human plague and being reverse result in plague preventionactivities.Materials and MethodsStudy was used data of rodent for zoonotic diseases suspicious which tested plague in National centerfor zoonotic disease (NCZD) in 2005-2015 and 13 local center for zoonotic diseases in 1988-2015. Datawas kept in NCZD and National archival authority. For mapping we used Arc View 3.2.ResultsTotally 397 event information of suspicious rodents and other animals was received in NCZD from 8 districtsof Ulaanbaatar city in 2002-2015. Most of information was received from Songinokhairkhan-64.2%district and smallest number was from Nalaikh district-0.3%. 92.2% of them were marmot, 0.1% of themwere marmot raw products for treatment purpose. Totally 1285 animal samples were tested by plaguedisease and the result was negative. Five hundred thirty tree marmots were carried to Ulaanbaatar from10 provinces. In that time plague foci were active and Y.pestis was isolated in provinces which marmotwas carried to Ulaanbaatar.In 1988-2015, totally 257 marmots and animals of 515 event information was received in15 provinces.Including 13.2% of them were birds, 84% of them marmot, 1.6% of them were livestock, 1.2% of themother animals. About 216 marmots were tested by plague. 51.2% of them were detected positive results.We develop conclusion based laboratory investigation result even it need high cost to take earlyprevention and response measures.Conclusion1. It is high risk to spread plague by carrying suspicious animal in urban area. Therefore, it is importantto take early response measures even it high cost. In further, increase cost and support rapid test ofhigh technology.2. To organize rational advertisement and increase knowledge of population about not doing illegalhunting, not selling marmot raw products in urban area, not using marmot raw products for treatmentuse and avoid contact with marmot carcasses.3. It is important to cooperate joint response measures with policeman, inspection agency andveterinary and human health sectors in Mongolia.